This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.
Beilstein J. Org. Chem. 2017, 13, 644–647, doi:10.3762/bjoc.13.63
Graphical Abstract
Scheme 1: Top: The natural product deoxynojirimycin and two analogues and marketed drugs Glyset and Zavesca. ...
Scheme 2: Synthesis of Boc- and Pht-protected diene substrates for endoperoxide synthesis. TBA-Cl = tetrabuty...
Scheme 3: Synthesis of endoperoxides 17–19 by [4 + 2]-cycloaddition of dienes 14–16 with singlet oxygen. The ...
Scheme 4: Dihydroxylation and protection of endoperoxides 18 and 19 to provide novel building blocks 20–23 fo...
Beilstein J. Org. Chem. 2013, 9, 1383–1387, doi:10.3762/bjoc.9.154
Figure 1: Marketed calcium-sensing receptor agonist cinacalcet (1), and CaSR antagonists Calhex 231 (2) and N...
Scheme 1: Strategy for assembling (R)-3 from fragments 4, 5 and 6. m-Ns = m-nitrobenzenesulfonyl.
Scheme 2: Synthesis of amine building block 6 by using Katritzky’s pyrylium chemistry [16].
Scheme 3: Synthesis of phenol 4 from commercially available aryl fluoride 13.
Scheme 4: Synthesis of rac-3 and (R)-3 from commercially available racemic- and (S)-glycidol 15, respectively...
Figure 2: Determination of the optical purity for (R)-3 by chiral HPLC on a Daicel AD-H column. Top: Opticall...
Figure 3: Characterisation of concentration-dependent (R)-3 inhibition of 3.5 mM calcium-stimulated IP1 respo...
Beilstein J. Org. Chem. 2013, 9, 641–646, doi:10.3762/bjoc.9.72
Figure 1: Hypothesised glucuronidation of GHB (1) by UDP-glucuronosyltransferase to give glucuronide 2. UDP =...
Scheme 1: Schmidt glucuronidation [11] with trichloroacetimidate 3. Synthesis of 4 and 5 using acceptors 7 and 8 ...
Scheme 2: Koenigs–Knorr glucuronidation [27] with bromide 10 and acceptors 7 and 8.
Scheme 3: Synthesis of GHB glucuronides 2 and d4-2 by using a Koenigs–Knorr glucuronidation approach. TEMPO: ...
Figure 2: 1H NMR spectrum (D2O, 300 MHz) of GHB glucuronides 2 (top) and d4-2 (bottom). As anticipated, methy...
Figure 3: 1H NMR spectra (500 MHz) of GHB glucuronide 2 in pH 4.8 buffer at t = 0 (rt) and t = 72 h (90 °C) b...